For a cleaner appearance:
I would reduce the width on the chat frames and move the MiniMap into the bottom "bar". Like this:
Action Bars | Chat Frame1 | Chat Frame2 | Combat Log | MiniMap
Use only one chat time stamp mod, either Nurfed's or Prat's. Disable the other mod's time stamps
Maybe tweak the combat log for a more Nurfed or Simple Combat Log type of appearance. This can be through the various filters now available in game.
Hide the chat menu icon and have your chat boxes the same height as your action bars. This will give you more screen real estate.
Do you use all the features of Prat or do you use just the "out of the box" setup? If so consider switching to Chatter.
I am not sure what MiniMap you are using, however maybe find one that "intergrates" the Tracking icon into the map.
If you can, have your "Trades" bar hidden, but appear upon mouse over.
Anyway, that's my two Eurocent's worth.