I use a combination of my own QuestClicks (
http://www.wowinterface.com/download...estClicks.html) which does quest items, Combinable Motes, Prospects, Milling, and the like along with LunarSphere (
http://www.wowinterface.com/download...narSphere.html) which has "detachable" (you can even hide the sphere itself if you want) buttons that are programmable to do things like "Best Food/Water", "Highest HP Potion", etc).
In my current setup, I have 4 buttons detached from LunarSphere and placed in pairs on the opposite edges of my screen. The 4 buttons are all "menu" buttons that pop open with up to 12 buttons in them. One "menu" holds my tradeskill buttons, one combat-useful items (potions, bandages, etc), one my utility items (I'm an engineer, so my pocket knife, Moll-E, Mote Extractor, etc) and one has misc goodies like call/revive pet, mounts, etc.