Sounds like something has gone wrong somewhere in the loading process.
Try unchecking all addons except for nUI and see if it goes away. Then slowly add your addons until you find the one that makes it go wrong.
That said, if this is your first try at nUI. My suggestion is to stop at just nUI enabled and play with it a bit and see what is missing. Then see which of your addons cover that and the others you should be able to get rid of.
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