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The issue you are binging up is a known problem for some players and discussed extensively in quite a few threads. It is a large part of the motivation for the rewrite in nUI6.
One working solution for raiding in the short term is to switch out of the 25 man raid unit frame panel to the solo or party panel which is doable unless you're a healer. This will greatly reduce the impact nUI has on framerate for those people who are affected by this bug.
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