Actually, with that amount of screen real estate you could probably get away with pretty much anything. Just make sure all the vital information is either on each side of your character or right under his feet. Maybe with a reduced opacity so as to not obstruct the view too much. Anything else can be safely tucked away in corners.
Maybe something like this:
http://www.wowinterface.com/forums/a...5&d=1284071396
I used that right before I quit. I think it was pretty centered, and, like you, I hated having to move my eyes around to find what I needed. Just to give you an idea
