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That sounds more like a problem on your side, WoW should be remembering your keybinds by default and shouldn't be wiping them.
Are you running WoW as an Administrator? (On Windows Vista or 7, right click the icon and choose "Run as Administrator")
Is the game crashing or are you Alt+F4 or otherwise exiting the game? It will only save them if you /camp, /exit or use the menu Logout and Exit commands.
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