Also worth mentioning is that on such a resolution, it is no longer possible to set your UI scale to a "pixel perfect" one (where one pixel in the UI matches one pixel on your monitor, ensuring crisp textures - most advanced UIs set this automatically) using the default UI scale. The bigger your resolution the lower you have to set the UI scale, however the default one doesn't go below 64% (0.64). I wrote the addon
UIScaler to work around this problem by enforcing the scale of the UI regardless of the setting.